How do arenediazonium salts behave in deep eutectic solvents? A combined experimental and computational approach

• Synthesis of new DESs and DES–like systems based on polyols as HBDs halide salts HBAs. Innovative DES design approach inspired by the necessity rigorous classification true DESs. Unveiling reduction process diazonium in a formed glycerol potassium fluoride. Mechanistic study DFT calculations electrochemical measurements. Combined theoretical experimental promotes an unprecedented successful insight chemistry Despite growing use Deep Eutectic Solvents (DESs) green reaction media number organic syntheses, no significant reactions these solvents are known literature. In this paper, we present behavior arenediazonium tetrafluoroborates salts/polyol-based DESs, nature which is investigated means combined computational approach. A relatively fast (strictly depending electronic effects substituents bound to aromatic ring) occurs initiated formation glycerolate-like species proved thorough aiming at elucidating involved mechanism.